CSRM617 hydrochloride 是转录因子 ONECUT2 (OC2，雄激素受体 AR 的主要调节剂) 的选择性小分子抑制剂，在 SPR 测定中 Kd 为 7.43 uM，直接与 OC2-HOX 结构域结合。CSRM617 hydrochloride 通过切割 Caspase-3 和 PARP 诱导细胞凋亡 (apoptosis)。CSRM617 hydrochloride 在小鼠的前列腺癌模型中耐受性良好。

Cholesteryl Hemisuccinate Tris Salt is an acidic cholesteryl ester with hepatoprotective and anticancer activity.Cholesteryl hemisuccinate is a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing Chaikosaponin-d, which enhances the anticancer efficacy of cisplatin.Cholesteryl hemisuccinate possesses antitumor activity, inhibits tumor Cholesteryl hemisuccinate has antitumor activity, inhibits tumor growth, inhibits the hepatotoxicity of acetaminophen (AAP) and prevents AAP-induced apoptosis of hepatocytes.Cholesteryl hemisuccinate protects rodents against the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform, and galactosamine.

CMLD-2 是一种 HuR-ARE 相互作用 的抑制剂。CMLD-2 竞争性结合 HuR 蛋白，破坏其与富含腺嘌呤-尿苷元素 (ARE) 的 mRNA 靶标的相互作用 (Ki=350 nM)。CMLD-2 可诱导凋亡并在结肠癌，胰腺癌，甲状腺癌和肺癌细胞系中表现出抗肿瘤活性。Hu 抗原 R (HuR) 是一种 RNA 结合蛋白，可以调节靶标 mRNA 的稳定性和翻译。